The Science

Automatic Retinal Imaging and Analysis (ARIA)

Retinal vessels are the only visible vessels and accessible by simple funds photography. Retinal vessels have the same embryo origin and histological structure with cerebral vessels. It provides us a convenient way to assess the cardiovascular condition and reflects pathological change caused by diabetes and hypertension.Cardiovascular diseases such as stroke is the second most frequent cause of death worldwide. Ischemic strokes are caused by interruption of the blood supply, while hemorrhagic strokes result from the rupture of a blood vessel or an abnormal vascular structure. About 87% of strokes are ischemic. Currently, there is no effective screening method for stroke. Methods to assess the risk of stroke include ultrasound, computed tomography angiography (CTA), and magnetic resonance angiography (MRA). Ultrasound can be used to evaluate the vascular stenosis and assess blood flow velocity in the carotid artery. CTA and MRA can be used to detect large cerebrovascular abnormalities, but these techniques have relatively high cost and also invasive.Automatic Retinal Imaging and Analysis (ARIA) is an innovative BTI diagnostic device for monitoring Metabolic Syndrome in general and risk of stroke in general. ARIA is used for screening of cardiovascular risk such as stroke, and also indicated for diabetic retinopathy and age-related macular degeneration screening.ARIA is an algorithm built on the internet platform, it is easy use and fast. ARIA is non-invasive, automatic and fast, accurate, suitable for repeated use and supported by Big Data.Research results of ARIA show sensitivity and specificity for cardiovascular risk to be 94% and 96%, respectively. In a group of about 600 diabetes patients, ARIA is used to calculate the 5-year probability of stroke based on a single retinal image versus the risk equation based on blood HbA1C, urine albumin-creatinine ration, and history of CHD and showed a significant linear relationship.ARIA is expected to be launched in fall 2018 for community application. First phase after launch will see ARIA deployed in sites such as rehabilitation centers, medical health centers, optometry shops, large enterprises and community health